From Cells and Tissues to Clinical and Research - Histopathology

4 ECTS / Modular / English

This elective CU is a part of the training offer in the 2nd year.

Intended learning outcomes (knowledge, skills and competences to be developed by the students)

  • Know and understand the basic principles of disease (causes, mechanisms, lesion processes);
  • Acquire skills of observation and deduction to be able to identify and interpret morphological changes, and the tissue, cellular and molecular events responsible for the different types of pathology;
  • Acquire theoretical preparation and general practice in histopathology;
  • Train the selection and processing of biological samples; in optical, fluorescence and electron microscopy and in complementary morphological techniques (immunohistochemistry, in situ hybridization);
  • Demonstrate that morphological changes are a valuable tool for understanding the pathogenesis and clinical manifestations of disease and for basic and translational research;
  • Understand the importance of studying prognostic and therapeutic biomarkers in clinical practice;
  • Demonstration of knowledge and development of oral and written communication skills.



General themes:

  • Mechanisms and common and important morphological manifestations of human disease
  • Cellular adaptation and senescence
  • Injury and Cell Death
  • Inflammation
  • Causes of Disease
  • Cellular targets
  • Cellular accumulations
  • Tissue repair
  • Extracellular pathology
  • Neoplasms epidemiology
  • Neoplasms etiopathogenesis
  • Cancer biology
  • Epigenetics and Genetics
  • Invasion and metastases
  • Familial Cancer Risk
  • Signalling pathways
  • Tumoral progression

Practical themes:

  • Macroscopy, Techniques and methods in Pathology
  • Observation of histopathological preparations in optical microscopic
  • Practice selection of samples and processing samples for histo-pathological study
  • Execution and interpretation of immunohistochemistry and in situ hybridization techniques
  • Translational research in cancer: from bench to clinic application
  • Examples of translational studies using morphology
  • Morphological diagnosis of neoplasm